Publications

  • Ryu Matsuo, Haruhiko Motomura, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono; Fukuoka Stroke Registry Investigators
    Association between Ambient Temperature and Risk of Ischaemic Stroke: An Observational Cohort Study
    Neuroepidemiology. 2025 May 26:1-17
    環境気温と虚血性脳卒中の発症リスクとの関連を検討した結果、低気温は心原性脳塞栓症（CE）や大血管アテローム性脳梗塞（LAA）のリスク上昇と、高気温はCEのリスク低下と関連した。また、発症5日以内に低温が続いていた場合にLAAのリスクが高まり、気温変動が大きいほどCEが起こりやすくなることが明らかになった。
  • Noriko Sato, Fumi Kiyuna, Kayo Wakisaka, Yuichiro Ohya, Kana Ueki, Sohei Yoshimura, Kuniyuki Nakamura, Jun Hata, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Ryu Matsuo; Fukuoka Stroke Registry Investigators
    Clinical Outcomes following Acute Ischaemic Stroke in Patients with Comorbid Cancer
    Cerebrovasc Dis. 2025 Mar 19:1-16
    急性期虚血性脳卒中患者において、癌の併存は独立した予後不良のリスク因子であり、特に活動性がん患者では3ヵ月後の機能予後不良や死亡のリスクが有意に上昇した。他に、癌と診断された時期や特定の癌（肝、胆道系、膵臓、大腸）は3ヵ月後機能予後不良のより高リスクと関連していた。
  • Fumi Irie, Kuniyuki Nakamura, Ryu Matsuo, Yoshinobu Wakisaka, Tetsuro Ago, Takanari Kitazono, Masahiro Kamouchi; Fukuoka Stroke Registry Investigators
    Factors related to sex differences in long-term functional decline after acute ischemic stroke
    Sci Rep. 2025 Apr 18;15(1):13400
    虚血性脳卒中後の5年間における機能予後をmRSスコアの変化に基づいて検討した結果、女性は男性に比べて機能低下のリスクが高く、特に75歳以上の高齢者および上下肢麻痺を有さない患者においてその傾向が顕著であった。
  • Kiyohara T, Matsuo R, Irie F, Nakamura K, Hata J, Wakisaka Y, Kitazono T, Kamouchi M, Ago T; Investigators for Fukuoka Stroke Registry.
    Functional outcome prediction in Japanese patients with non-surgical intracerebral hemorrhage: The FSR ICH Score.
    Cerebrovasc Dis. 2025 Jan 8:1-15
    保存的治療を受けた急性期脳出血（ICH）患者を対象に、年齢、糖尿病、発症前の認知症、入院時のNIHSSスコア、脳室内出血、血腫体積を基にした「FSR ICHスコア」を開発し、3ヵ月後の機能予後不良の予測に有用性を示した。
  • Ohya Y, Irie F, Nakamura K, Kiyohara T, Wakisaka Y, Ago T, Matsuo R, Kamouchi M, Kitazono T; Investigators for Fukuoka Stroke Registry
    Association between pulse pressure and risk of acute kidney injury after intracerebral hemorrhage
    Hypertens Res. 2024
    内科的管理を行った急性期脳出血患者において、入院時の高い脈圧は急性腎障害の発症リスクの増加と有意に関連しており、頭蓋内出血後の急性腎障害の予測因子となる可能性がある。
  • Irie F, Matsuo R, Mezuki S, Wakisaka Y, Kamouchi M, Kitazono T, Ago T; Fukuoka Stroke Registry Investigators.
    Effect of smoking status on clinical outcomes after reperfusion therapy for acute ischemic stroke.
    Sci Rep. 2024;14:9290.
  • Irie F, Matsumoto K, Matsuo R, Nohara Y, Wakisaka Y, Ago T, Nakashima N, Kitazono T, Kamouchi M
    Predictive performance of machine learning–based models for poststroke clinical outcomes in comparison with conventional prognostic scores: multicenter, hospital-based observational study
    JMIR AI 3:e46840
  • Wakisaka K, Matsuo R, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators.
    Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke.
    PLoS One. 2024 Jan 11;19(1):e0296833.
    脳梗塞発症時に腹囲が大きい患者では、BMIやインスリン抵抗性とは独立して、３ヵ月後機能予後良好と有意に関連していた。
  • Mezuki S, Matsuo R, Irie F, Shono Y, Kuwashiro T, Sugimori H, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators.
    Body temperature in the acute phase and clinical outcomes after acute ischemic stroke.
    PLoS One. 2024 Jan 11;19(1):e0296639.
    虚血性脳卒中発症後７日間の平均体温の５分位値を用いた検討では、入院時重症度、CRP、感染症などの交絡因子を調整後も、平均体温が高いほど臨床経過（入院後の神経症状改善または増悪）、および３ヵ月後機能転帰が不良であった。
  • Nakamura K, Ueki K, Matsuo R, Kiyohara T, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Investigators for Fukuoka Stroke Registry.
    Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study
    PLoS One. 2023 Jun 29;18(6):e0287721.
    急性期脳梗塞において、入院後の血清尿酸値の低下は、発症3ヶ月後の機能転帰不良と有意に関連する。
  • Wakisaka K, Matsuo R, Matsumoto K, Nohara Y, Irie F, Wakisaka Y, Ago T, Nakashima N, Kamouchi M, Kitazono T.
    Non-linear association between body weight and functional outcome after acute ischemic stroke.
    Sci Rep. 2023 May 29;13(1):8697.
    正常体重群と比較して、低体重群では急性期虚血性脳卒中発症3ヵ月後の機能予後不良となるリスクは有意に上昇し、過体重群では有意にリスクが低下したが、肥満群では有意な関連を示されなかった。
  • Ueki K, Matsuo R, Kuwashiro T, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators.
    Decreased Estimated Glomerular Filtration Rate and Proteinuria and Long-Term Outcomes After Ischemic Stroke: A Longitudinal Observational Cohort Study
    Stroke. 2023 Apr 6. doi: 10.1161/STROKEAHA.122.040958. Epub ahead of print. PMID: 37021567.
    腎機能低下（eGFRの低下）や腎障害（蛋白尿）は、虚血性脳卒中発症後の長期における脳卒中再発と死亡の互いに独立した危険因子である。
  • Ohya Y, Matsuo R, Sato N, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Investigators for Fukuoka Stroke Registry.
    Modification of the effects of age on clinical outcomes through management of lifestyle-related factors in patients with acute ischemic stroke.
    J Neurol Sci. 2023 Feb 15;446:120589.
    高年齢は、臨床的特徴、臨床病型、超急性期血栓溶解療法とは無関係に、脳梗塞発症後の臨床経過（入院後の神経症状改善または増悪）、および３ヵ月後機能転帰不良と有意に関連する。この関連は、女性、低体重、高血圧、糖尿病がある場合により強くなる可能性がある。
  • Irie F, Matsuo R, Nakamura K, Wakisaka Y, Ago T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.
    Sex Differences in Long-Term Functional Decline after Ischemic Stroke: A Longitudinal Observational Study from the Fukuoka Stroke Registry.
    Cerebrovasc Dis. 2023 Feb 8:1-8.
  • Ohya Y, Matsuo R, Sato N, Irie F, Nakamura K, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Investigators for Fukuoka Stroke Registry.
    Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study.
    PLoS One. 2022 Jul 13;17(7):e0268481.
    若年成人の脳梗塞は、非若年成人と比べて他の原因による脳梗塞（other determined etiology）や原因不明の脳梗塞（undetermined etiology）が多いが、高血圧、糖尿病、脂質異常症といった従来の危険因子や、喫煙、飲酒、肥満といった生活習慣に関連した因子は年齢が上がるにつれて増加するため、若年成人においても軽視することはできない。
  • Fukuda K, Matsuo R, Kamouchi M, Kiyuna F, Sato N, Nakamura K, Hata J, Wakisaka Y, Ago T, Imaizumi T, Kai H, Kitazono T; FSR Investigators.
    Day-by-Day Blood Pressure Variability in the Subacute Stage of Ischemic Stroke and Long- Term Recurrence.
    Stroke. 2022 Jan;53(1):70-78.
    虚血性脳卒中の亜急性期における血圧の日内変動は、長期的な脳卒中再発および全死亡の独立した予測因子である。
  • Irie F, Matsuo R, Nakamura K, Wakisaka Y, Ago T, Kamouchi M, Kitazono T, Fukuoka Stroke Registry Investigators
    Sex Differences in the Risk of 30-Day Death After Acute Ischemic Stroke
    Neurol Clin Pract. 2021 Dec;11(6):e809-e816
  • Wakisaka Y, Matsuo R, Nakamura K, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators.
    Pre-Stroke Cholinesterase Inhibitor Treatment Is Beneficially Associated with Functional Outcome in Patients with Acute Ischemic Stroke and Pre-Stroke Dementia: The Fukuoka Stroke Registry.
    Cerebrovasc Dis. 2021;50(4):390-396.
  • Kiyohara T, Matsuo R, Hata J, Nakamura K, Wakisaka Y, Kamouchi M, Kitazono T, Ago T; FSR Investigators.
    β-Cell Function and Clinical Outcome in Nondiabetic Patients With Acute Ischemic Stroke.
    Stroke. 2021;52(8):2621-2628.
    非糖尿病患者の急性期脳梗塞発症時における膵β細胞の機能低下（低HOMA-β）は、インスリン抵抗性と独立して、３ヵ月後機能予後不良および急性期増悪の危険因子である。
  • Matsuo R, Ago T, Kiyuna F, Sato N, Nakamura K, Kuroda J, Wakisaka Y, Kitazono T; Fukuoka Stroke Registry Investigators.
    Smoking Status and Functional Outcomes After Acute Ischemic Stroke.
    Stroke. 2020;51(3):846-852.
  • Sato N, Matsuo R, Kiyuna F, Nakamura K, Hata J, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; collab on behalf of the Fukuoka Stroke Registry Investigators.
    Anticoagulation and Risk of Stroke Recurrence in Patients with Embolic Stroke of Undetermined Source Having No Potential Source of Embolism.
    Cerebrovasc Dis.2020;49(6):601-608.
  • Kuroda J, Matsuo R, Yamaguchi Y, Sato N, Kamouchi M, Hata J, Wakisaka Y, Ago　T, Kitazono T; Fukuoka Stroke Registry Investigators.
    Poor glycemic control and　posterior circulation ischemic stroke.
    Neurol Clin Pract. 2019;9(2):129-139.
  • Shono Y, Sugimori H, Matsuo R, Fukushima Y, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators.
    Safety of antithrombotic therapy for patients with acute ischemic stroke harboring unruptured intracranial aneurysm.
    Int J Stroke. 2018; 13(7):734-742.
  • Ago T, Matsuo R, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.
    Insulin resistance and clinical outcomes after acute ischemic stroke.
    Neurology. 2018; 90(17): e1470-1477.
    虚血性脳卒中急性期のHOMA-IRの5分位値を用いた検討では、高HOMA-IRは神経学的予後（入院中の神経学的重症度の改善または増悪）、および３ヵ月後機能転帰不良の危険因子であった。この関連は、糖尿病や非肥満患者でも同様に示された。
  • Kiyuna F, Sato N, Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.
    Association of Embolic Sources With Cause-Specific Functional Outcomes Among Adults With Cryptogenic Stroke.
    JAMA Netw Open. 2018;1(5):e182953.
  • Ogata T, Matsuo R, Kiyuna F, Hata J, Ago T, Tsuboi Y, Kitazono T, Kamouchi M; FSR Investigators.
    Left Atrial Size and Long-Term Risk of Recurrent Stroke After Acute Ischemic Stroke in Patients With Nonvalvular Atrial Fibrillation.
    J Am Heart Assoc. 2017; 6.
  • Wakisaka Y, Matsuo R, Hata J, Kuroda J, Kitazono T, Kamouchi M, Ago T; Fukuoka Stroke Registry Investigators.
    Adverse Influence of Pre-Stroke Dementia on Short-Term Functional Outcomes in Patients with Acute Ischemic Stroke: The Fukuoka Stroke Registry.
    Cerebrovasc Dis. 2017;43(1-2):82-89.
  • Matsuo R, Yamaguchi Y, Matsushita T, Hata J, Kiyuna F, Fukuda K, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.
    Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke.
    Stroke. 2017;48:3049-3056.
  • Ishikawa H, Wakisaka Y, Matsuo R, Makihara N, Hata J, Kuroda J, Ago T, Kitayama J, Nakane H, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators.
    Influence of Statin Pretreatment on Initial Neurological Severity and Short-Term Functional Outcome in Acute Ischemic Stroke Patients: The Fukuoka Stroke Registry.
    Cerebrovasc Dis. 2016; 42(5-6): 395-403.
  • Matsuo R, Michikawa T, Ueda K, Ago T, Nitta H, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.
    Short-Term Exposure to Fine Particulate Matter and Risk of Ischemic Stroke.
    Stroke. 2016;47(12):3032-3034.
  • Matsuo R, Ago T, Hata J, Wakisaka Y, Kuroda J, Kuwashiro T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.
    Plasma C-Reactive Protein and Clinical Outcomes after Acute Ischemic Stroke: A Prospective Observational Study.
    PLoS One. 2016;11(6):e0156790.
  • Nakamura A, Kuroda J, Ago T, Hata J, Matsuo R, Arakawa S, Kuwashiro T, Yasaka M, Okada Y, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.
    Causes of Ischemic Stroke in Patients with Non-Valvular Atrial Fibrillation.
    Cerebrovasc Dis. 2016;42(3-4):196-204.
  • Fukuda K, Kai H, Kamouchi M, Hata J, Ago T, Nakane H, Imaizumi T, Kitazono T; FSR Investigators; steering committee of the Fukuoka Stroke Registry included.
    Day-by-Day Blood Pressure Variability and Functional Outcome After Acute Ischemic Stroke: Fukuoka Stroke Registry.
    Stroke. 2015;46(7):1832-9.
  • Irie F, Kamouchi M, Hata J, Matsuo R, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators.
    Sex differences in short-term outcomes after acute ischemic stroke: the fukuoka stroke registry.
    Stroke. 2015;46(2):471-6.
  • Matsuo R, Kamouchi M, Fukuda H, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators.
    Intravenous thrombolysis with recombinant tissue plasminogen activator for ischemic stroke patients over 80 years old: the Fukuoka Stroke Registry.
    PLoS One. 2014;9(10):e110444.
  • Ogata T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Ago T, Sugimori H, Inoue T, Kitazono T; Fukuoka Stroke Registry.
    Gastrointestinal bleeding in acute ischemic stroke: recent trends from the fukuoka stroke registry.
    Cerebrovasc Dis Extra. 2014;4(2):156-64.
  • Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Hata J, Gotoh S, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T; REBIOS Investigators.
    Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke.
    J Neurol Sci. 2014;340(1-2):75-9.
  • Matsuo R, Kamouchi M, Ago T, Hata J, Shono Y, Kuroda J, Wakisaka Y, Sugimori H, Kitazono T; FSR investigators.
    Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke: Fukuoka Stroke Registry.
    Geriatr Gerontol Int. 2014;14(4):954-9.
  • Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators.
    High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry.
    Hypertension. 2014;63(1):54-60.
  • Kiyohara T, Kamouchi M, Kumai Y, Ninomiya T, Hata J, Yoshimura S, Ago T, Okada Y, Kitazono T; Fukuoka Stroke Registry Investigators.
    ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack.
    Stroke. 2014;45(2):418-25.
  • Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T.
    Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke – Research for Biomarkers in Ischemic Stroke (REBIOS).
    Metabolism. 2014;63(9):1093-103.
  • Matsuo R, Ago T, Hata J, Kuroda J, Wakisaka Y, Sugimori H, Kitazono T, Kamouchi M; FSR Investigators.
    Impact of the 1425G/A polymorphism of PRKCH on the recurrence of ischemic stroke: Fukuoka Stroke Registry.
    J Stroke Cerebrovasc Dis. 2014;23(6):1356-61.
  • Kuwashiro T, Sugimori H, Ago T, Kuroda J, Kamouchi M, Kitazono T.
    The impact of predisposing factors on long-term outcome after stroke in diabetic patients: the Fukuoka Stroke Registry.
    Eur J Neurol. 2013;20(6):921-7.
  • Kamouchi M, Sakai H, Kiyohara Y, Minematsu K, Hayashi K, Kitazono T.
    Acute kidney injury and edaravone in acute ischemic stroke: the Fukuoka Stroke Registry.
    J Stroke Cerebrovasc Dis. 2013;22(8):e470-6.
  • Kuwashiro T, Sugimori H, Ago T, Kuroda J, Kamouchi M, Kitazono T; FSR Investigators.
    Predictive role of C reactive protein in stroke recurrence after cardioembolic stroke: the Fukuoka Stroke Registry.
    BMJ Open.2013;3(11):e003678.
  • Makihara N, Kamouchi M, Hata J, Matsuo R, Ago T, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators.
    Statins and the risks of stroke recurrence and death after ischemic stroke: the Fukuoka Stroke Registry.
    Atherosclerosis. 2013;231(2):211-5.
  • Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T.
    Clinical significance of plasma VEGF value in ischemic stroke – research for biomarkers in ischemic stroke (REBIOS) study.
    BMC Neurol. 2013;13:32.
  • Tokami H, Ago T, Sugimori H, Kuroda J, Awano H, Suzuki K, Kiyohara Y, Kamouchi M, Kitazono T; REBIOS Investigators.
    RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke.
    Brain Res. 2013;1517:122-32.
  • Nakamura A, Ago T, Kamouchi M, Hata J, Matsuo R, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators.
    Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke: the Fukuoka Stroke Registry.
    Stroke. 2013;44(11):3239-42.
  • Kuwashiro T, Kamouchi M, Ago T, Hata J, Sugimori H, Kitazono T.
    The factors associated with a functional outcome after ischemic stroke in diabetic patients: the Fukuoka Stroke Registry.
    J Neurol Sci. 2012;313(1-2):110-4.